The Race for the Ebola Vaccine

<p class="p1"><i>According to a <a href="http://www.who.int/mediacentre/news/releases/2015/effective-ebola-vaccine/en/" target="_blank">statement</a> from WHO Friday, Merck & Co.’s </i><span class="s1"><i>VSV-EBOV </i></span><i>vaccine has proven “highly effective,” with 100 percent efficacy in clinical trials. The vaccine was developed by an Ames-Iowa based pharmaceutical called NewLink and commissioned by the Public Health Agency of Canada. </i></p><br/><p class="p1"><i>The following was originally published on Wednesday, January 7, 2015.</i></p><br/>The need for an <a href="http://www.thedailybeast.com/features/ebola.html">Ebola</a> vaccine in West Africa has never been greater.<br/><br/>While public interest in Ebola continues to dwindle, the epidemic itself continues to soar. On Tuesday, the World Health Organization reported more than 20,000 cases of the disease in West Africa, nearly half of them in Sierra Leone. The death toll, which experts believe has been significantly undercut by secret burials, stands at 7,905. With a mortality rate of 70 percent, the more cases that arise, the deadlier this epidemic becomes.<br/><br/>Although a few smaller companies have become involved in the race for a vaccine, three major pharmaceutical makers are taking the lead—each pursuing a different vaccine. The trials are unprecedented for a variety of reasons, including the rapid timeline (trials of this nature generally take three to four years). Each individual race involves an unusual collaboration between researchers, manufacturers, and public-health entities. Together, the teams are working 24 hours a day for a product that promises much higher risk than it does profit.<br/><br/>Here’s what you need to know about the Ebola vaccine front-runners.<br/><br/><b>1. Johnson & Johnson (J&J)</b><br/><br/><b>Status: </b>Phase 1, first in human trials at University of Oxford<b><br/>Type: </b>Two-shot vaccine, specifically targeting the Zaire species of Ebola<br/><br/>The U.S. drug giant made <a href="http://www.bloomberg.com/news/2015-01-06/j-j-starts-ebola-vaccine-trial-in-u-k-increases-output.html" target="_blank">headlines</a> Tuesday with the news that human trials of its experimental Ebola vaccine are now underway in the U.K. Although a late entry to the race—its announcement came in September—J&J has quickly stolen the spotlight. In October, the company pledged more than $200 million to fast track its unique vaccine, which takes a two-pronged approach to immunizing a patient against Ebola.<br/><br/>Seventy-two adults between the ages of 18 and 50 are participating in the trial, led by the pediatrics department at Oxford. The accelerated vaccine utilizes two different treatments—the first to “prime” the patient’s immune system, and the other to “boost” it—each manufactured by separate international biotechnical companies (one, Denmark-based Bavarian Nordic; the other, Netherlands-based Crucell). If successful, Johnson & Johnson <a href="http://www.marketwatch.com/story/johnson-johnson-begins-humans-testing-of-ebola-vaccine-2015-01-06" target="_blank">plans</a> to have as many as 400,000 doses available by April, and up to 5 million by the end of the year.<br/><br/><b>2. GlaxoSmithKline (GSK)</b><br/><br/><b>Status: </b>Phase 2, administering the vaccine to thousands of Ebola workers<b><br/>Type: </b>Two different specific strains of Ebola delivered via a chimpanzee carrier virus<br/><br/>British drug behemoth GlaxoSmithKline got a head start on J&J, partnering with the National Institute of Allergy and Infectious Diseases (NIAID) to begin human trials of an experimental Ebola vaccine in late August. GSK’s involvement springs from Okairos, a Swiss-Italian biotechnology company that it acquired in 2013. The vaccine was co-developed by Okairos and a team of American scientists led by Dr. Nancy J. Sullivan, chief of Biodefense Research Section in NIAID’s Vaccine Research Center.<br/><br/>The NIAID/DSK vaccine is different from J&J’s in that it contains segments of the Ebola virus’s genetic material from two different strains: Zaire (this current outbreak) and Sudan. The vaccine is <a href="http://www.nih.gov/news/health/nov2014/niaid-28.htm" target="_blank">delivered</a> through a “carrier virus” that causes a common cold in chimpanzees but does not affect humans. Twenty adults in Bethesda, Maryland, were injected with the vaccine for the Phase 1 trial in August. The trials produced positive results, published in <em>The</em> <i>New England Journal of Medicine</i> in November. Four weeks after the injections, all 20 of the participants had developed the antibodies needed to stave off the infection. The next phase of the trial consists of vaccinating Ebola workers on the front lines. A date has yet to be announced.<br/><br/><b>3. Merck & Co.</b><br/><br/><b>Status: </b>Phase 1, restarting first in human trials at lower dose due to complaints of joint pain<b><br/>Type: </b>Genetically engineered version of vesicular stomatitis virus (VSV)<br/><br/>Decidedly the underdog in this fight is American pharmaceutical company Merck & Co., whose effort rests on a tiny Ames, Iowa-based biotechnology company called NewLInk Genetics Corp. Merck bought the rights to NewLink’s vaccine in late November, a treatment that was initially commissioned by the Public Health Agency of Canada in 2011 for $200,000.<br/><br/>NewLink’s vaccine, VSV-Zebov, is “based in part on a genetically engineered version of vesicular stomatitis virus (VSV).” The gene for the outer protein of the VSV virus, which is incredibly rare in humans, is replaced with a segment of the gene from the Ebola Zaire species. The company began Phase 1 first in human trials in December, after getting approval from the Federal Drug Administration. But the trials, conducted at the University Hospitals of Geneva, were halted when volunteers reported joint pain as a result of the injection. The Phase 1 trials are set to resume this week, using a lower dose of the vaccine.

The Race for the Ebola Vaccine

According to a statement from WHO Friday, Merck & Co.’s VSV-EBOV vaccine has proven “highly effective,” with 100 percent efficacy in clinical trials. The vaccine was developed by an Ames-Iowa based ph…

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Wanna See Some Sexy Self Shots?

Girls love posing and taking pictures on their iPhones and guys like us love every minute of it. But there’s a difference between taking a selfie and taking a sexy self shot. Who cares about selfies of a girl ready to go out to dinner or doing their makeup? We want to see sexy self shots with girls in their underwear or next to nothing at all. If you’re here to see selfies, then try Instagram. But if you’re here to see sexy self shots, you’re in the right place.<br/><br/><img alt="" src="http://41.media.tumblr.com/5ac125fe9cb350a2ad989742542ee21c/tumblr_nntsjf6wfD1t7i3g5o1_1280.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/c4220f673cf2c46eae3bd170b2b42bd9/tumblr_nnhpb7zaiH1r51124o1_1280.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/89095feaa51eb06ef6c5898bcf2b7cb2/tumblr_nnmebvtoNz1qixedeo1_1280.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/c5d4619d1a0ff3a715e85f1decbc6a67/tumblr_nll2mtsb951stijv1o1_1280.jpg" /><br/><br/><img alt="" src="http://36.media.tumblr.com/fa35bdc8b7fa996e00167b34d77fc85c/tumblr_nn00aw2CiN1qcv90wo1_1280.jpg" /><br/><br/><img alt="" src="http://36.media.tumblr.com/ba181b6098efab7f736d8a5faf01f05e/tumblr_nnsf97S3vd1s97etwo1_1280.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/8c60eb883ac4fdbc8bf690cc3131eb78/tumblr_nnhbpwA2L51rk0vseo1_1280.jpg" /><br/><br/><img alt="" src="http://36.media.tumblr.com/be19d9b4e448b4f9561161d0b498ca83/tumblr_nnhpbskyH91r51124o1_1280.jpg" /><br/><br/><img alt="" src="http://40.media.tumblr.com/86f7b35467c9fa75f8144050e9661209/tumblr_nny5lmezGg1t7i3g5o1_1280.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/955b00e3b34062b9c30956d33f4a7ce6/tumblr_nnu4pzGCb51r51124o1_1280.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/5ddaafd43cec171205918a75d4a17cef/tumblr_nmdyk7hqWf1t7i3g5o1_1280.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/037beaacc80e36e5f5f39b8aace5c270/tumblr_ne8bafaC151smjc75o1_1280.jpg" /><br/><br/><img alt="" src="http://36.media.tumblr.com/dabe9b1ddf1c15198e31fc7d00fdfb07/tumblr_nl1uu9UDVn1tnrxd2o1_500.jpg" /><br/><br/><img alt="" src="http://40.media.tumblr.com/2bd6767ad9f0d4b30a6f5a4081cb8a9e/tumblr_nks1krvpBO1rd9aino1_1280.jpg" /><br/><br/><img alt="" src="http://40.media.tumblr.com/f9226cb96ea7f9a91e78ca250fdb6e85/tumblr_nn6eznPPpY1r51124o1_1280.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/6d9f4e610165616ae6d503c10b642864/tumblr_nmrburBted1usf78to1_1280.jpg" /><br/><br/><img alt="" src="http://36.media.tumblr.com/0e2f09af207786fdcf14df409e0b10da/tumblr_nh8z8oe8bw1redclao1_500.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/f52f56d3c772c2463eaccc165a54bef5/tumblr_nmnue1DKXe1uqe6w1o1_1280.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/6e98434e8541ae57fceebfc539245a06/tumblr_nnvukdvj541r51124o1_1280.jpg" /><br/><br/><img alt="" src="http://36.media.tumblr.com/88c02efb1acab38d7dfba41c96922ad4/tumblr_nkhrsgtfPL1smjc75o1_1280.jpg" /><br/><br/><img alt="" src="http://36.media.tumblr.com/e138fb8f3dda7a0c4ac5b402e2cd161c/tumblr_nndb3kHqfp1qjrdq8o1_1280.jpg" /><br/><br/><img alt="" src="http://40.media.tumblr.com/65c3e25c541248fea7e453f0d03d4bc7/tumblr_nm3yglQ8Tf1qzdpaio1_1280.jpg" /><br/><br/><img alt="" src="http://40.media.tumblr.com/4846272b3689152481ecb70100073ca9/tumblr_n98ki8Kcqm1qjsn5wo1_1280.jpg" /><br/><br/><img alt="" src="http://41.media.tumblr.com/9a70d9cc2a25a2d0c3fa977e3cc770d7/tumblr_nj5tng0OQ31u9ar3uo1_540.jpg" /><br/><br/><img alt="" src="http://img.izismile.com/img/img7/20140310/640/sexy_selfies_are_womens_gifts_to_men_640_41.jpg" /><br/><br/><img alt="" src="http://img.izismile.com/img/img7/20140310/640/sexy_selfies_are_womens_gifts_to_men_640_11.jpg" /><br/><br/><img alt="" src="http://acidcow.com/pics/20140311/hot_selfies_shots_46.jpg" /><br/><br/><img alt="" src="http://img.izismile.com/img/img7/20140310/640/sexy_selfies_are_womens_gifts_to_men_640_22.jpg" /><br/><br/> 

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Wanna See Some Sexy Self Shots?

Girls love posing and taking pictures on their iPhones and guys like us love every minute of it. But there’s a difference between taking a selfie and taking a sexy self shot. Who cares about selfies o…

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Internet’s Booty Hall of Fame!

<img alt="" src="http://s.likes-media.com/img/0d1b16c98742f1f79fadda95fc5cb4b3.600x.jpg" /><br/><br/><img alt="" src="http://s.likes-media.com/img/a48037263cdd1e6b362193194719c593.600x.jpg" /><br/><br/><img alt="" src="https://thechive.files.wordpress.com/2014/10/booty-hof-14.jpg" /><br/><br/><img alt="" src="https://thechive.files.wordpress.com/2014/10/booty-hof-10.jpg" /><br/><br/><img alt="" src="https://s-media-cache-ak0.pinimg.com/236x/18/fe/6a/18fe6a50aab8bdb818cce095f27b4278.jpg" /><br/><br/><img alt="" src="https://hoodkings.files.wordpress.com/2012/06/carib-booty.jpg" /><br/><br/><img alt="" src="http://lh3.ggpht.com/NJdGyeB1vw_x4HXxdi5tUf71LUEzrGdLMSCYG6kAUvThIQHEirymTJYpYw3DI3KT-0Gg" /><br/><br/><img alt="" src="http://i825.photobucket.com/albums/zz175/Phil_is_2_raw/panama-cricket-has-the-best-booty.jpg" /><br/><br/><img alt="" src="https://thechive.files.wordpress.com/2012/05/hot-volleyball-booty-butts-humps-10.jpg" /><br/><br/><img alt="" src="http://s.likes-media.com/img/ba50972a836031f33a1f3185483032dc.600x.jpg" /><br/><br/><img alt="" src="http://s.likes-media.com/img/f553d9852b6b740ede9851af5e3ac4cd.600x.jpg" /><br/><br/><img alt="" src="http://s.likes-media.com/img/c3542c240d58718833c9f83ac156f7c6.600x.jpg" /><br/><br/><img alt="" src="http://s.likes-media.com/img/69de26e64dd0b8162039b63315aa4874.600x.jpg" /><br/><br/><img alt="" src="http://s.likes-media.com/img/689c597bf98e31be6a9c0b0c079943c1.600x.jpg" /><br/><br/> 

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Internet’s Booty Hall of Fame!

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How to disable Cortana from the task bar in Windows 10

One of the prominent new features in the task bar in <a href="http://www.windowscentral.com/windows-10">Windows 10</a> is the<a href="http://www.windowscentral.com/cortana">Cortana</a> search box to the right of the Start button. It's a really great tool to have close at hand, but, it does also use up quite a bit of real estate. So, it's understandable you might want to make it go away – especially if you can't use Cortana right now.<br/><br/>Fortunately, that's really simple.<br/><br/><img alt="" class="image-large_wm_blw aligncenter image-large" height="413" src="http://www.windowscentral.com/sites/wpcentral.com/files/styles/larger_wm_blw/public/field/image/2015/07/cortana-taskbar-menu-w10.jpg?itok=-F-C25BN" width="800" /><br/><br/>The search box will be enabled by default when you fire up Windows 10 for the first time. To make it go away, follow these steps:<br/><ol><br/> <li>Right click on the task bar.</li><br/> <li>Select the "Search" option.</li><br/> <li>You'll now see three new options for what to do. To make it go away altogether hit "Disabled."</li><br/> <li>If you still want to keep it but want more space on the task bar, select "Show search icon" and the box will be replaced by a little magnifying glass icon.</li><br/> <li>To make it all come back again follow the same steps but hit the option to enable the search box.</li><br/></ol>

How to disable Cortana from the task bar in Windows 10

One of the prominent new features in the task bar in Windows 10 is theCortana search box to the right of the Start button. It's a really great tool to have close at hand, but, it does also use up quit…

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Stylish wireless charging phones could be on their way at last

Wireless charging is pretty awesome, as it means you can just place your compatible smartphone on a charging pad (basically a drinks coaster with a USB port) and the battery will start recharging – no more hunting around in the dark for a cable when you top up your phone at night.<br/><br/>There is a problem though, as smartphones with wireless charging need plastic backs to enable the charge to pass through – which meant those of us who could wirelessly charge would often look on in envy at the metal-clad slabs of gorgeousness others were toting.<br/><br/>Thankfully the clever boffins at Qualcomm have come up with a way to allow Rezence chargers (the name of the wireless tech some phones use) to wirelessly charge devices with metal backs.<br/><br/>Ditching the jargon, this means we no longer have to choose between wireless charging or a fancy looking – and feeling – handset, and it could usher in a wave of gorgeously designed full-metal smartphones capable of cable-free power ups.<br/><br/>Samsung is one of the big believers in wireless charging (with its <a href="http://www.t3.com/reviews/samsung-galaxy-s6-review-1">Galaxy S6</a> and<a href="http://www.t3.com/reviews/samsung-galaxy-s6-edge-review">S6 Edge</a> flagships coming with the technology), so lets hope the technology giant leads the way in bringing us some drool-worthy all metal wireless devices soon.

Stylish wireless charging phones could be on their way at last

Wireless charging is pretty awesome, as it means you can just place your compatible smartphone on a charging pad (basically a drinks coaster with a USB port) and the battery will start recharging – no…

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Samsung Galaxy S6 Edge Plus 16 Megapixel Camera Confirmed

As well as the Galaxy Note 5, Samsung will announced the <a href="http://www.geeky-gadgets.com/samsung-galaxy-s6-edge-plus-may-have-4gb-of-ram-27-07-2015/">Samsung Galaxy S6 Edge Plus</a> and their press event on the 13th of August.<br/><br/>We previously heard that the Samsung Galaxy S6 Edge Plus would come with a 16 megapixel rear camera, this has now been confirmed by India’s import database, Zauba.<br/><br/>The handset is listed on Zauba with a 16 megapixel camera, the same camera that is used on the Galaxy S6 and Galaxy S6 Edge, the device will come with a 5 megapixel front camera.<br/><br/>Other specifications on the New Galaxy S6 Edge Plus include a 5.7 inch QHD display with a resolution of 2560 x 1440 pixels, the handset will be powered by a Samsung Exynos 7420 processor and will come with 4GB of RAM.<br/><br/>We will have more details on this new version of the S6 Edge along with the new Galaxy Note 5 when it is announced next month.

Samsung Galaxy S6 Edge Plus 16 Megapixel Camera Confirmed

As well as the Galaxy Note 5, Samsung will announced the Samsung Galaxy S6 Edge Plus and their press event on the 13th of August.We previously heard that the Samsung Galaxy S6 Edge Plus would come wit…

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Elecom’s New Dual-Band WiFi Router With Hardware NAT Function

Elecom is about to launch their newest dual-band WiFi router namely the WRC-1900GHBK-A. Corresponding to the ‘Draft 11ac’ (the new standard for Wireless LAN IEEE802.11ac), this home router is configured with one Internet LAN port and four LAN ports, and supports for dual-band WiFi access point (2.4GHz – 600Mbps and 5GHz – 1300Mbps).<br/><br/>Furthermore, the WRC-1900GHBK-A comes with hardware NAT function – wired throughput up to 940Mbps and provides security through encryption using WPA2-PSK (AES), WPA-PSK (TKIP) and WEP (128/64-bit).<br/><br/>Measuring W26mm x D130mm x H182.5mm and weighing 219 grams, the WRC-1900GHBK-A will hit the market from mid-August for 19,159 Yen (about $155).

Elecom’s New Dual-Band WiFi Router With Hardware NAT Function

Elecom is about to launch their newest dual-band WiFi router namely the WRC-1900GHBK-A. Corresponding to the ‘Draft 11ac’ (the new standard for Wireless LAN IEEE802.11ac), this home router is configur…

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Razer will make good on Ouya’s indie dev debts

One of the big pushes made with the launch of the Ouya game console was the Free the Games Fund. When Razer bought the Ouya name and software this week, word initially was that Razer wouldn’t be touching the outstanding debt, but it looks like that’s not the case.<br/><br/>The Free the Games Fund had Ouya matching, with some limitations, crowdfunding raised by developers to help them get their games going on the new console. 27 developers joined the program and were promised in total about $1 million dollars. A few of the developers reached their goals and got their funding, while another bunch received some of it. At the time of the sale, though, over a half million dollars was left unpaid.<br/><br/>Razer’s deal didn’t include the hardware or the fund, but in speaking to <em>Polygon</em>, Razer CEO Min-Liang Tan said that that since Razer is backing the Ouya publishing arm, they “are going to try to make good on this fund and give these developers an option.”<br/><br/>The developers who sign on with Razer are no longer obligated to remain exclusive to the Ouya platform, but to receive the funds – which Razer is under no legal obligation to provide – they’ll be required to give away some copies of the game on the Ouya storefront once the game is finished. Tan gave the example of a developer publishing a $10 game and receiving $10,000 in funding having to give away 1,000 copies of the game. Razer is basically treating it something like guaranteed sales.<br/><br/>This is an interesting compromise that seems to be very beneficial to the developers. If they can meet their milestones and put the game out, they’re guaranteed that a certain number of copies of the game will be out there in the wild, giving them some potential word of mouth while they put the game out on other stores instead of having to wait.

Razer will make good on Ouya’s indie dev debts

One of the big pushes made with the launch of the Ouya game console was the Free the Games Fund. When Razer bought the Ouya name and software this week, word initially was that Razer wouldn’t be touch…

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OnePlus 2: 10 different ways to win the new smartphone

Can’t wait to get your hands on the <a href="http://www.technobuffalo.com/videos/oneplus-2-hands-on-video/">OnePlus 2</a>? The Chinese phone-maker just launched a new contest offering 10 different ways to win the handset for free. All you need to do is pick a challenge, complete it and send in a video for proof for a chance to win one of 22 units.<br/><br/>There are a ton of different options to choose from, but all them seem to focus on giving OnePlus some free publicity. That seems like a fair deal though, especially if the result is a free smartphone for you.<br/><br/>For example, you can give your car a OnePlus-themed makeover or project the company’s logo in the middle of a busy city. Other options include organizing a flash mob, creating a viral dance video, performing a song or poem about the OnePlus 2, promoting the device on social media, or running through a live event wearing a OnePlus shirt. You can even create a new app for the OnePlus community.<br/><br/>In case you missed our earlier coverage, we’re pretty excited about the OnePlus 2. The new phone packs a ton of cutting edge hardware, including a fingerprint reader and USB-C. It also features a fresh design with metal edges and customizable back panels.<br/><br/>The contest is only running for five more days, so hit the source link now to get started. You may also want to get in line for a chance to receive an invitation in case you don’t end up winning a free OnePlus 2.

OnePlus 2: 10 different ways to win the new smartphone

Can’t wait to get your hands on the OnePlus 2? The Chinese phone-maker just launched a new contest offering 10 different ways to win the handset for free. All you need to do is pick a challenge, compl…

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Samsung to 'adjust' pricing of the Galaxy S6 and S6 edge to maintain sales momentum

In its Q2 2015 <a href="http://www.androidcentral.com/samsungs-q2-2015-earnings-point-slight-bump-mobile-revenue">earnings report</a>, Samsung announced that it will keep sales momentum going for the <a href="http://www.androidcentral.com/samsung-galaxy-s6">Galaxy S6</a> and <a href="http://www.androidcentral.com/samsung-galaxy-s6-edge">Galaxy S6 edge</a> into the latter half of the year by "adjusting" their pricing:<br/><blockquote>While the IT & Mobile Communications (IM) Division is expected to face a difficult business environment, the sales momentum for high-end products will be maintained by adjusting the price of the Galaxy S6 and S6 edge and introducing new premium smartphone models.</blockquote><br/>The new premium smartphone models are expected to be the <a href="http://www.androidcentral.com/samsung-galaxy-note-5">Galaxy Note 5</a> and<a href="http://www.androidcentral.com/tag/samsung-galaxy-s6-edge-plus">Galaxy S6 edge+</a>, which will likely be unveiled at Samsung's upcoming <a href="http://www.androidcentral.com/samsung-announces-galaxy-unpacked-event-august-13">Unpacked event</a> from New York on August 13.<br/><br/>Samsung didn't mention when it will initiate the price change, but with the latest sales figures from <em>Strategy Analytics</em> showing the manufacturer <a href="http://www.androidcentral.com/huawei-surpasses-microsoft-become-third-largest-smartphone-vendor-world">losing market share</a> during the last quarter, it will likely be sooner rather than later.

Samsung to 'adjust' pricing of the Galaxy S6 and S6 edge to maintain sales momentum

In its Q2 2015 earnings report, Samsung announced that it will keep sales momentum going for the Galaxy S6 and Galaxy S6 edge into the latter half of the year by "adjusting" their pricing:While the IT…

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Canon's New Camera Sees More In the Dark Than You Ever Thought Possible

<p class="first-text" data-textannotation-id="3ab1df4208896498a603bf3142c38355">Anyone who’s ever been frustrated at the task of shooting video in low light should be poised to freak out over Canon’s weird and amazing new camera. It’s a video camera that shoots full HD color footage in almost complete darkness.</p><br/><p data-textannotation-id="362fceae039520423773bcef000f5a74">The ‘multi-purpose’ camera, dubbed only MH20F-SH, has a full-frame sensor with 2.26 megapixels. The reason for the meager resolution is because each pixel is very large—19 microns to be exact. That’s 7.5x larger than, say, the pixels found on a flagship DSLR like the Canon 1Dx. Huge pixels mean they can capture a huge amount of light.</p><br/><p data-textannotation-id="3bf02540c141153ac7912e7606902857">In this case, Canon’s sensor reaches an insane 4,000,000 ISO. Yeah, four million. Basically it sees better in the dark than you can. Remember, this is without infrared night vision tricks. It’s normal color 1080p video at 24, 30, or 60 fps.</p><br/><p data-textannotation-id="8a9dc3c0cbe4852f238da31b52835a1e">Weirdly, Canon doesn’t have any sample footage from the camera, so we can’t see for ourselves what it can do. But, we do have a video from 2013 that was released when this technology was under development:</p><br/><p data-textannotation-id="e58e4e922dec6384687d672f5a980ef6"><span class="flex-video widescreen"><iframe id="viddler-129479ff" src="http://www.viddler.com/embed/129479ff/?f=1&autoplay=false&player=mini&disablebranding=0;offset=0&autoplay=0" width="640" height="360" frameborder="0" scrolling="no" allowfullscreen="allowfullscreen" data-chomp-id="129479ff"></iframe></span></p><br/><p data-textannotation-id="eccdcfa923c67f94b35b76500cc7f459">Before you get excited at what this means for your gritty neo-noir short film set in an dark alley, let me tell you that this camera is not meant for most consumers. First off, it’s $30,000. And it’s made for “industrial” uses. Not sure what that really means, but Canon mentioned things like nighttime surveillance and wildlife documentaries. Something tells me many crazies will think of other cool uses for it. It’s pretty small, at about 4 x 4 x 4 inches, so that will make it versatile for interesting shooting situations.</p><br/><p class="has-media media-640 has-image" data-textannotation-id="3a242af488e0f547eca05651090210cb"><span class="lightBoxWrapper"><span class="img-border"><img alt="Canon's New Camera Sees More In the Dark Than You Ever Thought Possible" class="js_annotatable-image cursor-crosshair" data-asset-url="http://i.kinja-img.com/gawker-media/image/upload/s--JU3iaa_f--/c_fit,fl_progressive,q_80,w_636/1363455045838197419.jpg" data-chomp-id="1363455045838197419" data-format="jpg" data-original-src="https://i.kinja-img.com/gawker-media/image/upload/1363455045838197419.jpg" height="318" src="http://i.kinja-img.com/gawker-media/image/upload/s--JU3iaa_f--/c_fit,fl_progressive,q_80,w_636/1363455045838197419.jpg" width="636" /></span></span></p><br/><p data-textannotation-id="3eba90ea82caccc91bb4d86437ce2580">The point of this seems to be for Canon to show off that it still innovates. It’s taken quite a lot of heat from camera enthusiasts in the past couple of years for falling behind in bringing new and forward-thinking features to market. Though proving people wrong with a $30,000 device is an interesting way to go.</p><br/><p data-textannotation-id="37960922e667b541d7174542b623f40c">In any case, we can all look forward to eye-popping nighttime footage coming out of this thing in the near future when the camera ships in December.</p>

Canon's New Camera Sees More In the Dark Than You Ever Thought Possible

Anyone who’s ever been frustrated at the task of shooting video in low light should be poised to freak out over Canon’s weird and amazing new camera. It’s a video camera that shoots full HD color foot…

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New Moto G adds 4G LTE, 13-megapixel camera for $180

If it ain't broke, don't fix it. That appears to be Motorola's stance with its budget-friendly <a href="http://www.cnet.com/products/motorola-moto-g-review/">Moto G</a> smartphone. The newly announced third-generation model retains many of the qualities users loved in the older models, while adding a faster processor, an improved camera, and making the phone water-resistant up to 1M for 30 minutes.<br/><br/>Hardware, however, is only half of the story when it comes to the Moto G. A large part of what has made the phone so popular is the price, and that's not going to change. The third-generation <a href="http://www.cnet.com/uk/products/motorola-moto-g/" data-is-autolink="true">Moto G </a>will be available for $180 without a contract. That price converts to about £115 in the UK and AU$250 in Australia.<br/><br/>The Moto G is equipped with the same 5-inch 1,280 x 720-pixel resolution display as last year's model. That works out to about 293 pixels per inch, which is just shy of the <a href="http://www.cnet.com/uk/products/apple-iphone-6/" data-is-autolink="true">iPhone 6</a> (326 ppi). While the design is largely the same, the phone has received a welcomed hardware boost.<br/><br/>The phone is powered by a 1.4GHz quad-core Snapdragon 410 processor with Adreno 306 graphics. A major complaint with last year's model was the lack of 4G LTE support. This has been addressed in the new Moto G, which includes LTE support on all models.<br/><br/><figure class="image image-small<br/> pull-right"><span class="imageContainer"><img alt="motogwhitefrontback.jpg" class="" data-original=" http://cnet4.cbsistatic.com/hub/i/r/2015/07/28/a6be9b85-dca5-472a-9fff-32b5e0aafe65/resize/270xauto/7a26d10f8e2ae539f9d53200d1fc7858/motogwhitefrontback.jpg" height="auto" src="http://cnet4.cbsistatic.com/hub/i/r/2015/07/28/a6be9b85-dca5-472a-9fff-32b5e0aafe65/resize/270xauto/7a26d10f8e2ae539f9d53200d1fc7858/motogwhitefrontback.jpg" width="270" /></span><figcaption><span class="credit">Motorola</span></figcaption></figure>The rear camera has also received a boost from 8-megapixels to 13. While the front has been bumped up from 2- to 5-megapixels. Other features include a MicroSD card slot for extra storage and a battery that, according to Motorola, will last more than 24 hours with mixed usage.<br/><br/>Last year's Moto G featured a special nano-coating that helped the phone withstand water splashing, however it was never intended to be fully submerged. This third-generation model now carries a water-resistant rating of IPX7, which means it can be fully submerged in a meter of water for up 30 minutes.<br/><br/>The new Moto G will also be the first of Motorola's budget phones to be available from the company's MotoMaker website, which was previously only available for Moto X. This allows users to customize the phone's front, side and back colors, along with choosing storage capacity and special welcome greetings.<br/><br/>Two configurations will be available at launch. The base model is equipped with 8GB of internal storage and 1GB of RAM. If that's not enough storage for you, however, there is also a slightly more expensive model with 16GB of internal storage and 2GB of RAM.<br/><br/>The Moto G is available in over 60 countries starting today.<br/><br/><em>This story is developing and will be updated with additional information.</em>

New Moto G adds 4G LTE, 13-megapixel camera for $180

If it ain't broke, don't fix it. That appears to be Motorola's stance with its budget-friendly Moto G smartphone. The newly announced third-generation model retains many of the qualities users loved i…

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This year's Moto G feels like another cheap champion

It's a little hard not to look at <a href="http://www.engadget.com/2015/07/28/motorola-moto-g-third-gen-india/">the Moto G</a> as one of the less interesting devices we saw today -- after all, it got unveiled in India well while plenty of us were sleeping and it was quickly overshadowed by the unlocked beauty of the <a href="http://www.engadget.com/2015/07/28/the-moto-x-style-is-big-gorgeous-and-of-course-highly-customi/">Moto X Style</a>. Motorola clearly doesn't see it the same way. The Moto G has been the best-selling smartphone in the company's history, and it had to make sure that this year's model struck a crucial balance between price and performance. We just got our own unit to fiddle around with, and so far, Motorola has another cheap champion on its hands.<br/><br/>As we know, this year's Moto G is powered by a 1.4GHz quad-core Snapdragon 410, but there's a there's crucial difference between the two major models available today. The baseline model — the one we just got — costs $179, but only has 8GB of storage and 1GB of RAM. In all likelihood, you're going to want the model starting at $219 since it has double the storage and RAM for, not accounting for all your MotoMaker add-ons.<br/><p class="image-container"><img alt="" data-credit="AOL" data-mep="898515" src="http://o.aolcdn.com/hss/storage/midas/e6308c30a3bbfa64d5c51ffd02c87901/202383068/p7280304.jpg" /></p><br/>Sussing out performance in situations like this is always a crapshoot, but the combination of some decent silicon and an almost-completely-stock version of Android 5.1.1 Lollipop mean there's not much room for hiccups just yet. Not everything worked the way it should right out of the gate, though. I spent a good 10 seconds trying to figure out why the on-screen shift key wouldn't work when punching in a WiFi password, and the despite setting the system language to English, the very first notification that popped up in my shade was something en Francais. Still haven't been able to figure that one out. Still, after installing some apps and taking the Chrome for a spin, I didn't notice much in the way of glaring slow-down. The Snapdragon 410 certainly won't blow you away, but at first blush it's easily <em>as</em> solid — if not moreso — than most of <a href="http://www.engadget.com/2015/07/22/unlocked-phone-shootout-meet-the-huawei-p8-lite-and-oppo-r7/">the other low-cost unlocked smartphones</a> I've played with lately. Smarter features like Moto Assist work just as well as they always have too, which only helps Motorola stand out from the madding crowd.<br/><p class="image-container"><img alt="" data-credit="AOL" data-mep="898516" src="http://o.aolcdn.com/hss/storage/midas/394db93783d3617632b0da35b24fca21/202383070/p7280296.jpg" /></p><br/>So yes, the Moto G is finally starting to feel a little more premium -- thankfully looks are catching up too. There's still a sizable bezel running around the 5-inch 720p screen, but the addition of a metallic accent around the 13-megapixel camera and flash add a welcome dose of style to the thing. Oh, and there's a very good chance your Moto G will look better than ours since you'll be able to run it through the MotoMaker wringer, choosing your own colors for the accents and backplates. While I'm rambling on about the Moto G's back, it's been said that it has the same camera as the Nexus 6. Turns out that's not the full story. Yes, the Moto G uses the same 13-megapixel Sony sensor as its much bigger cousin and a similar f/2.0 aperture lens. The differences lie in the way the elements around it are constructed -- the lens is loaded up with IR-filtering coatings that help the camera handle ambient light more intelligently. I haven't spent too much time with the thing yet, but early results are pretty impressive -- it more accurately exposed a photo of me in a darkish room than a similarly priced Samsung phone.<br/><br/>It's obviously way too early to start passing judgment on this thing, but one thing seems clear from the get-go: Motorola still knows how to make a good, cheap phone. We'll update this story with more nuanced impressions as they develop, and stay tuned for our full review in the days to come.

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This year's Moto G feels like another cheap champion

It's a little hard not to look at the Moto G as one of the less interesting devices we saw today -- after all, it got unveiled in India well while plenty of us were sleeping and it was quickly oversha…

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Top 10 Best Cigarette Brands

<h2>10. GOLDFLAKE</h2><br/><a href="http://listcrux.com/wp-content/uploads/2014/01/goldflake.jpg"><img alt="goldflake" class="alignnone size-medium wp-image-15896" height="225" src="http://listcrux.com/wp-content/uploads/2014/01/goldflake-300x225.jpg" width="300" /></a><br/><br/>Made from the bright golden yellow tobacco flakes, enriched with honeydew flavour, goldflakes are awesome middle range cigarettes from ITC Limited, the leading tobacco company in India. Besides Wills Gold Flake there are other brands that make goldflake cigarettes too, including Bacons’ Gold Flake, Hignett’s Golden Flaked Honey Dew, Salmon and Gulckstein’s Gold Flake.They come in a wide range of varieties and qualities – Gold Flake Kings (84 mm), Gold Flake Kings Lights (84mm), Gold Flake and Gold Flake Lights. These cigarettes are quite smooth and the flavour of the smoke is quite exhilarating. If the smoke is inhaled to a deeper extent the taste is enjoyed to the maximum. Also, the smaller ones are cheaper and better than any other cigarette in this range. If you want to live life king-size, you have got to smoke a goldflake kings!<br/><h2>9. INSIGNIA</h2><br/><a href="http://listcrux.com/wp-content/uploads/2014/01/insignia.jpg"><img alt="insignia" class="alignnone size-medium wp-image-15895" height="233" src="http://listcrux.com/wp-content/uploads/2014/01/insignia-300x233.jpg" width="300" /></a><br/><br/>This is another grand cigarette from the house of ITC limited. Considered as one of the most expensive cigarettes in India, Insignia smokes are at par with some of the best international luxury brands like John Player Black, Cartier, Dunhill and Sobranie. They come in attractive matt black packages and are sold in a single variety. These cigarettes are known for the smoothness in the flow of the tobacco smoke through the filter and the associated taste. If you are one of those who believe not just in quality but in class too, this is exactly what you might be looking for to refresh your spirits!<br/><h2>8. BENSON & HEDGES</h2><br/><a href="http://listcrux.com/wp-content/uploads/2014/01/Bension-hedges1.jpg"><img alt="Bension hedges" class="alignnone size-medium wp-image-15894" height="195" src="http://listcrux.com/wp-content/uploads/2014/01/Bension-hedges1-300x195.jpg" width="300" /></a><br/><br/>If you want the taste of pure Virginia tobacco, get a taste of these English cigarettes. The smoke is quite moderate and does not ruin one’s throat. It is a great choice for those who prefer cigarettes that are neither too strong nor too weak in flavour of the smoke. These cigarettes come in different varieties like Gold, Silver, White and Gold Superkings, and rolling tobacco. They were the first to introduce the concept of ‘dual-flavoured’ cigarettes, which included a pork-gelatine capsule in the filter to alter the taste of the smoke if desired. B&H has been one of the most famous and widely available good cigarettes in the world since 1873.<br/><h2>7. PALL MALL</h2><br/><a href="http://listcrux.com/wp-content/uploads/2014/01/pall-mall.jpg"><img alt="pall mall" class="alignnone size-medium wp-image-15892" height="192" src="http://listcrux.com/wp-content/uploads/2014/01/pall-mall-300x192.jpg" width="300" /></a><br/><br/>It is one of the highest selling brands of cigarettes by R. J. Reynolds Tobacco Company. It was one of the first in the segment of premium cigarettes and had set standards in design and taste for both short and long cigarettes. Their technique of stuffing the tobacco is quite unique and the added charcoal is like the icing on the cake! They are sold in a number of varieties like Red, Blue, Orange, Green, Black and White which refers to the different strengths of the tobacco and menthol content of the cigarettes. They had even come up with 100mm long cigarettes, which however did not last long due to market competition. These are the best one can get in this price range.<br/><h2>6. CAMEL</h2><br/><a href="http://listcrux.com/wp-content/uploads/2014/01/camel.jpg"><img alt="camel" class="alignnone size-medium wp-image-15891" height="300" src="http://listcrux.com/wp-content/uploads/2014/01/camel-300x300.jpg" width="300" /></a><br/><br/>This American brand of cigarettes was the first to introduce the concept of pre-rolled tobacco for smoking. They developed a flavour of their own using the best of Virginia and Turkish tobacco. The packaging of Camel cigarettes has been quite famous because of their attractive graphic design and catchy quotes, besides the use of Turkish paper in the fashion of Egyptian cigarettes. These cigarettes burn quite evenly and smoothly, thus leaving an impression of the superior flavour for a long time. They are also quite richer in tar and nicotine content than most other cigarettes. If you are a fan of cigarettes, this is a must smoke for you!<br/><div></div><br/><h2>5. LUCKY STRIKE</h2><br/><a href="http://listcrux.com/wp-content/uploads/2014/01/lucky-strike.jpg"><img alt="lucky strike" class="alignnone size-medium wp-image-15890" height="225" src="http://listcrux.com/wp-content/uploads/2014/01/lucky-strike-300x225.jpg" width="300" /></a><br/><br/>These American smokes have been one of the top selling cigarettes of all times. They are specifically famous for the use of roasted tobacco rather than the form dried in the sun, which is supposed to enhance the flavour and make the cigarettes more desirable. It was introduced in Virginia as chewing tobacco and later shifted to making pre-rolled filtered cigarettes. ‘Luckies’ have been one of the most favoured cigarettes by women of all time, because of the smooth taste and richness of flavour. Some of the varieties are made stronger in taste with natural additives, though the natural ones are equally unique and distinctive.<br/><h2>4. DUNHILL</h2><br/><a href="http://listcrux.com/wp-content/uploads/2014/01/dunhill.jpg"><img alt="dunhill" class="alignnone size-medium wp-image-15889" height="236" src="http://listcrux.com/wp-content/uploads/2014/01/dunhill-300x236.jpg" width="300" /></a><br/><br/>If you want to smoke some real quality, Dunhill is what you might be looking for. Made by the British American Tobacco company, they are one of the most expensive luxury brands in the line of cigarettes available. They are available in nearly all over the globe and are priced higher than the other cigarettes in the same class. They are available in a large number of varieties having different contents of nicotine and tar. People love Dunhill for the unique smell and the lingering taste of spiciness and undertones of sweetness. What more! The Dunhill switch comes with a bubble of mint in the filter, which can be used to release a rich blend of minty taste in the mouth.<br/><h2>3. PARLIAMENT</h2><br/><a href="http://listcrux.com/wp-content/uploads/2014/01/parliament.jpg"><img alt="parliament" class="alignnone size-medium wp-image-15888" height="225" src="http://listcrux.com/wp-content/uploads/2014/01/parliament-300x225.jpg" width="300" /></a><br/><br/>One doesn’t simply smoke a Parliament for no reason. If you had caught a glimpse of Charlie Sheen in their ads in the 1990s, you would of course know what we are talking about. Filtered cigarettes became popular not before the 1950s. Marketed by the company Philip Morris, these were the first of cigarettes to have recessed paper filters that allows only the nicotine to reach the smokers mouth. They come in varieties including menthol flavoured, and different sizes – Green Pack (Menthol Full Flavour), White Pack (Menthol Lights) Kings and Silver Pack (Menthol Ultra Lights) Kings. They are known for their excellent taste and light smell. Their unique filters make them low in tar content and thus a favourite among those who dislike the harsh smell of cigarettes.<br/><h2>2. DAVIDOFF</h2><br/><a href="http://listcrux.com/wp-content/uploads/2014/01/davidpff.jpg"><img alt="davidoff" class="alignnone size-medium wp-image-15887" height="300" src="http://listcrux.com/wp-content/uploads/2014/01/davidpff-300x300.jpg" width="300" /></a><br/><br/>The unique taste and style is what sets Davidoff cigarettes apart from the rest of them and makes them one of the most elite in the line of luxury cigarette brands. Currently owned by Imperial Tobacco, the brand markets a range of cigars, cigarettes and pipe tobaccos. The cigarette range includes varieties like the Magnum, Magnum Lights, Supreme, Classic, Mild, Lights, Slims, Super Slims, Ultra lights, Menthol, Menthol Lights, One and Gold. Davidoff also makes a line of cigars known as “Zino” and a line of cigarillos. They have made the Dominican premium cigars the number-one bestsellers worldwide. Davidoff cigarettes can make you feel the history, culture and tradition of rich and quality smoking. Once you taste the style of a Davidoff, you cannot simply go back to smoking something else!<br/><h2>1. MARLBORO</h2><br/><a href="http://listcrux.com/wp-content/uploads/2014/01/marlboro.jpg"><img alt="marlboro" class="alignnone size-medium wp-image-15886" height="225" src="http://listcrux.com/wp-content/uploads/2014/01/marlboro-300x225.jpg" width="300" /></a><br/><br/>You see a Marlboro everywhere, be it a magazine ad featuring Marlboro Man, or the world of motorsports. Made by the company Philip Morris, these are the largest selling cigarettes in the world. These elegant cigarettes were however, introduced for women in 1924, and emphasized on its feminine features, which included a red band to hide the lipstick stains from the filter! However, it gained its market among men after 1950, when the cigarettes began to be more generalised in make. Marlboro cigarettes come in a variety of flavours, sizes and packages all over the world. Marlboro cigarettes provide a completely different smoking experience, because of the strong yet smooth flavour. The brand is quite famous for its association with Formula 1 Grand Prix, as a sponsor for famous teams like BRM, Iso Marlboro-Ford, McLaren and Ferrari.

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Top 10 Best Cigarette Brands

10. GOLDFLAKEMade from the bright golden yellow tobacco flakes, enriched with honeydew flavour, goldflakes are awesome middle range cigarettes from ITC Limited, the leading tobacco company in India. B…

Read more »